Ontology highlight
ABSTRACT:
SUBMITTER: Valdes-Mora F
PROVIDER: S-EPMC5432295 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Valdés-Mora Fatima F Locke Warwick J WJ Bandrés Eva E Gallego-Ortega David D Cejas Paloma P García-Cabezas Miguel Angel MA Colino-Sanguino Yolanda Y Feliú Jaime J Del Pulgar Teresa Gómez TG Lacal Juan Carlos JC
Oncotarget 20170401 16
CDC42 is an oncogenic Rho GTPase overexpressed in colorectal cancer (CRC). Although CDC42 has been shown to regulate gene transcription, the specific molecular mechanisms regulating the oncogenic ability of CDC42 remain unknown. Here, we have characterized the transcriptional networks governed by CDC42 in the CRC SW620 cell line using gene expression analysis. Our results establish that several cancer-related signaling pathways, including cell migration and cell proliferation, are regulated by C ...[more]