Ontology highlight
ABSTRACT:
SUBMITTER: Kumazoe M
PROVIDER: S-EPMC5432527 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kumazoe Motofumi M Takai Mika M Hiroi Shun S Takeuchi Chieri C Yamanouchi Maasa M Nojiri Takashi T Onda Hiroaki H Bae Jaehoon J Huang Yuhui Y Takamatsu Kanako K Yamashita Shuya S Yamada Shuhei S Kangawa Kenji K Takahashi Takashi T Tanaka Hiroshi H Tachibana Hirofumi H
Scientific reports 20170515 1
Recurrence following chemotherapy is observed in the majority of patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that cancer stem cells (CSCs) may be involved in PDAC recurrence and metastasis. However, an efficient approach to targeting pancreatic CSCs remains to be established. Here we show that in cancer cells overexpressing the 67-kDa laminin receptor (67LR)-dependent cyclic GMP (cGMP) inducer, epigallocatechin-3-O-gallate (EGCG) and a phosphodiesterase 3 (PDE3) ...[more]