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A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy.

ABSTRACT: Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke-Blackburn-Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields.

SUBMITTER: Shao T

PROVIDER: S-EPMC5433183 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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A practical and efficient approach to imidazo[1,2-<i>a</i>]pyridine-fused isoquinolines through the post-GBB transformation strategy.

Shao Taofeng T Gong Zhiming Z Su Tianyi T Hao Wei W Che Chao C

Beilstein journal of organic chemistry 20170504

Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-<i>a</i>]pyridine-fused isoquinoline systems from readily available starting materials was achieved through the Groebke-Blackburn-Bienaymé reaction followed by a gold-catalyzed cyclization strategy. The synthetic approach is characterized by mild reaction conditions and a broad substrate scope, allowing for the rapid construction of structurally complex and diverse heterocycles in moderate to good yields. ...[more]

PMID: 28546839

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