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Synthesis of D-manno-heptulose via a cascade aldol/hemiketalization reaction.

ABSTRACT: A [4 + 3] synthesis of D-manno-heptulose is described. The cascade aldol/hemiketalization reaction of a C₄ aldehyde with a C₃ ketone provides the differentially protected ketoheptose building block, which can be further reacted to furnish target D-manno-heptulose.

SUBMITTER: Chen Y

PROVIDER: S-EPMC5433184 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Synthesis of D-manno-heptulose via a cascade aldol/hemiketalization reaction.

Chen Yan Y Wang Xiaoman X Wang Junchang J Yang You Y

Beilstein journal of organic chemistry 20170428

A [4 + 3] synthesis of D-manno-heptulose is described. The cascade aldol/hemiketalization reaction of a C4 aldehyde with a C3 ketone provides the differentially protected ketoheptose building block, which can be further reacted to furnish target D-manno-heptulose. ...[more]

PMID: 28546836

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