Ontology highlight
ABSTRACT:
SUBMITTER: Corridoni D
PROVIDER: S-EPMC5433921 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Corridoni D D Rodriguez-Palacios A A Di Stefano G G Di Martino L L Antonopoulos D A DA Chang E B EB Arseneau K O KO Pizarro T T TT Cominelli F F
Mucosal immunology 20161116 4
Although genetic polymorphisms in NOD2 (nucleotide-binding oligomerization domain-containing 2) have been associated with the pathogenesis of Crohn's disease (CD), little is known regarding the role of wild-type (WT) NOD2 in the gut. To date, most murine studies addressing the role of WT Nod2 have been conducted using healthy (ileitis/colitis-free) mouse strains. Here, we evaluated the effects of Nod2 deletion in a murine model of spontaneous ileitis, i.e., the SAMP1Yit/Fc (SAMP) strain, which c ...[more]