Comparative genomic expression signatures of signal transduction pathways and targets in paediatric Burkitt lymphoma: a Children's Oncology Group report.
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ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC5435544 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Comparative genomic expression signatures of signal transduction pathways and targets in paediatric Burkitt lymphoma: a Children's Oncology Group report.
Lee Sanghoon S Day Nancy S NS Miles Rodney R RR Perkins Sherrie L SL Lim Megan S MS Ayello Janet J van de Ven Carmella C Harrison Lauren L El-Mallawany Nader K NK Goldman Stanton S Cairo Mitchell S MS
British journal of haematology 20170504 4
Burkitt lymphoma (BL) is the most common histological subtype of non-Hodgkin lymphoma (NHL) in children and adolescents. Through the introduction of short intensive multi-agent chemoimmunotherapy, survival has improved significantly over the past 30 years. However, this successful approach is limited by significant chemotherapy-induced acute toxicity and risk of developing resistant disease, demonstrating the need to identify less toxic and targeted therapies. We analysed the comparative genomic ...[more]
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