Ontology highlight
ABSTRACT:
SUBMITTER: Heumann A
PROVIDER: S-EPMC5435682 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Heumann Asmus A Kaya Özge Ö Burdelski Christoph C Hube-Magg Claudia C Kluth Martina M Lang Dagmar S DS Simon Ronald R Beyer Burkhard B Thederan Imke I Sauter Guido G Izbicki Jakob R JR Luebke Andreas M AM Hinsch Andrea A Jacobsen Frank F Wittmer Corinna C Büscheck Franziska F Höflmayer Doris D Minner Sarah S Tsourlakis Maria Christina MC Schlomm Thorsten T Wilczak Waldemar W
Scientific reports 20170517 1
Y-box binding protein 1 (YB-1) is an RNA and DNA binding factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray with 11,152 prostate cancers was analysed by immunohistochemistry. Cytoplasmic and nuclear staining was separately analysed. Cytoplasmic YB-1 was absent or weak in normal epithelium but seen in 86,3% of carcinomas. Cytoplasmic staining was weak, moderate, and strong in 29.6%, 43.7% and 13.0% of tumours and was accompanied by nuclear YB-1 s ...[more]