Ontology highlight
ABSTRACT:
SUBMITTER: Rabbie R
PROVIDER: S-EPMC5435926 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rabbie Roy R Rashid Mamunur M Arance Ana M AM Sánchez Marcelo M Tell-Marti Gemma G Potrony Miriam M Conill Carles C van Doorn Remco R Dentro Stefan S Gruis Nelleke A NA Corrie Pippa P Iyer Vivek V Robles-Espinoza Carla Daniela CD Puig-Butille Joan A JA Puig Susana S Adams David J DJ
Pigment cell & melanoma research 20170419 3
Melanoma in young children is rare; however, its incidence in adolescents and young adults is rising. We describe the clinical course of a 15-year-old female diagnosed with AJCC stage IB non-ulcerated primary melanoma, who died from metastatic disease 4 years after diagnosis despite three lines of modern systemic therapy. We also present the complete genomic profile of her tumour and compare this to a further series of 13 adolescent melanomas and 275 adult cutaneous melanomas. A somatic BRAF<sup ...[more]