Ontology highlight
ABSTRACT:
SUBMITTER: Manjon E
PROVIDER: S-EPMC5435928 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Manjón Elvira E Edreira Tomás T Muñoz Sofía S Sánchez Yolanda Y
Nucleic acids research 20170501 9
Rho GTPases are conserved molecules that control cytoskeletal dynamics. These functions are expedited by Rho GEFs that stimulate the release of GDP to enable GTP binding, thereby allowing Rho proteins to initiate intracellular signaling. How Rho GEFs and Rho GTPases protect cells from DNA damage is unknown. Here, we explore the extreme sensitivity of a deletion mutation in the Rho1p exchange factor Rgf1p to the DNA break/inducing antibiotic phleomycin (Phl). The Rgf1p mutant cells are defective ...[more]