TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.
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ABSTRACT:
SUBMITTER: Marrone MC
PROVIDER: S-EPMC5436240 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.
Marrone Maria Cristina MC Morabito Annunziato A Giustizieri Michela M Chiurchiù Valerio V Leuti Alessandro A Mattioli Marzia M Marinelli Sara S Riganti Loredana L Lombardi Marta M Murana Emanuele E Totaro Antonio A Piomelli Daniele D Ragozzino Davide D Oddi Sergio S Maccarrone Mauro M Verderio Claudia C Marinelli Silvia S
Nature communications 20170510
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glut ...[more]
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