Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC5436585 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lee Mijoon M Domínguez-Gil Teresa T Hesek Dusan D Mahasenan Kiran V KV Lastochkin Elena E Hermoso Juan A JA Mobashery Shahriar S
ACS chemical biology 20160411 6
A family of 11 lytic transglycosylases in Pseudomonas aeruginosa, an opportunistic human pathogen, turn over the polymeric bacterial cell wall in the course of its recycling, repair, and maturation. The functions of these enzymes are not fully understood. We disclose herein that SltB3 of P. aeruginosa is an exolytic lytic transglycosylase. We characterize its reaction and its products by the use of peptidoglycan-based molecules. The enzyme recognizes a minimum of four sugars in its substrate but ...[more]