Dataset Information

Top-down control of cortical gamma-band communication via pulvinar induced phase shifts in the alpha rhythm.

ABSTRACT: Selective routing of information between cortical areas is required in order to combine different sources of information according to cognitive demand. Recent experiments have suggested that alpha band activity originating from the pulvinar coordinates this inter-areal cortical communication. Using a computer model we investigated whether top-down induced shifts in the relative alpha phase between two cortical areas could modulate cortical communication, quantified in terms of changes in gamma band coherence between them. The network model was comprised of two uni-directionally connected neuronal populations of spiking neurons, each representing a cortical area. We find that the phase difference of the alpha oscillations modulating the two neuronal populations strongly affected the interregional gamma-band neuronal coherence. We confirmed that a higher gamma band coherence also resulted in more efficient transmission of spiking information between cortical areas, thereby confirming the value of gamma coherence as a proxy for cortical information transmission. In a model where both neuronal populations were connected bi-directionally, the relative alpha phase determined the directionality of communication between the populations. Our results show the feasibility of a physiological realistic mechanism for routing information in the brain based on coupled oscillations. Our model results in a set of testable predictions regarding phase shifts in alpha oscillations under different task demands requiring experimental quantification of neuronal oscillations in different regions in e.g. attention paradigms.

SUBMITTER: Quax S

PROVIDER: S-EPMC5436894 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Top-down control of cortical gamma-band communication via pulvinar induced phase shifts in the alpha rhythm.

Quax Silvan S Jensen Ole O Tiesinga Paul P

PLoS computational biology 20170504 5

Selective routing of information between cortical areas is required in order to combine different sources of information according to cognitive demand. Recent experiments have suggested that alpha band activity originating from the pulvinar coordinates this inter-areal cortical communication. Using a computer model we investigated whether top-down induced shifts in the relative alpha phase between two cortical areas could modulate cortical communication, quantified in terms of changes in gamma b ...[more]

PMID: 28472057

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Project description:α-Synuclein is an intrinsically disordered protein that plays a critical role in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease. Proteomics studies of human brain samples have associated the modification of the O-linked N-acetyl-glucosamine (O-GlcNAc) to several synucleinopathies; in particular, the position of the O-GlcNAc can regulate protein aggregation and subsequent cell toxicity. There is a need for site specific O-GlcNAc α-synuclein screening tools to direct better therapeutic strategies. In the present work, for the first time, the potential of fast, high-resolution trapped ion mobility spectrometry (TIMS) preseparation in tandem with mass spectrometry assisted by an electromagnetostatic (EMS) cell, capable of electron capture dissociation (ECD), and ultraviolet photodissociation (213 nm UVPD) is illustrated for the characterization of α-synuclein positional glycoforms: T72, T75, T81, and S87 modified with a single O-GlcNAc. Top-down 213 nm UVPD and ECD MS/MS experiments of the intact proteoforms showed specific product ions for each α-synuclein glycoforms associated with the O-GlcNAc position with a sequence coverage of ∼68 and ∼82%, respectively. TIMS-MS profiles of α-synuclein and the four glycoforms exhibited large structural heterogeneity and signature patterns across the 8+-15+ charge state distribution; however, while the α-synuclein positional glycoforms showed signature mobility profiles, they were only partially separated in the mobility domain. Moreover, a middle-down approach based on the Val40-Phe94 (55 residues) chymotrypsin proteolytic product using tandem TIMS-q-ECD-TOF MS/MS permitted the separation of the parent positional isomeric glycoforms. The ECD fragmentation of the ion mobility and m/z separated isomeric Val40-Phe94 proteolytic peptides with single O-GlcNAc in the T72, T75, T81, and S87 positions provided the O-GlcNAc confirmation and positional assignment with a sequence coverage of ∼80%. This method enables the high-throughput screening of positional glycoforms and further enhances the structural mass spectrometry toolbox with fast, high-resolution mobility separations and 213 nm UVPD and ECD fragmentation capabilities.

Dataset Information

Top-down control of cortical gamma-band communication via pulvinar induced phase shifts in the alpha rhythm.

Publications

Top-down control of cortical gamma-band communication via pulvinar induced phase shifts in the alpha rhythm.

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