Ontology highlight
ABSTRACT:
SUBMITTER: Newie J
PROVIDER: S-EPMC5437038 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Newie Julia J Neumann Piotr P Werner Martin M Mata Ricardo A RA Ficner Ralf R Feussner Ivo I
Scientific reports 20170518 1
The biological function of lipoxygenases depends on the regio and stereo specific formation of fatty acid-derived hydroperoxides and different concepts exist to explain the mechanism that directs dioxygen to a specific carbon atom within the substrate. Here, we report the 1.8 Å resolution crystal structure of a cyanobacterial lipoxygenase that produces bis-allylic hydroperoxides (CspLOX2). Site directed mutagenesis experiments combined with computational approaches reveal that residues around th ...[more]