Ontology highlight
ABSTRACT:
SUBMITTER: Dorard C
PROVIDER: S-EPMC5437303 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Dorard Coralie C Estrada Charlène C Barbotin Céline C Larcher Magalie M Garancher Alexandra A Leloup Jessy J Beermann Friedrich F Baccarini Manuela M Pouponnot Celio C Larue Lionel L Eychène Alain A Druillennec Sabine S
Nature communications 20170512
NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse melanoma models, we investigate their contribution in tumour progression, from the onset of benign tumours to malignant tumour maintenance. We show that BRAF expression is required for ERK activation and ...[more]