Overexpression of antibiotic resistance genes in hospital effluents over time.

ABSTRACT:

Objectives

Effluents contain a diverse abundance of antibiotic resistance genes that augment the resistome of receiving aquatic environments. However, uncertainty remains regarding their temporal persistence, transcription and response to anthropogenic factors, such as antibiotic usage. We present a spatiotemporal study within a river catchment (River Cam, UK) that aims to determine the contribution of antibiotic resistance gene-containing effluents originating from sites of varying antibiotic usage to the receiving environment.

Methods

Gene abundance in effluents (municipal hospital and dairy farm) was compared against background samples of the receiving aquatic environment (i.e. the catchment source) to determine the resistome contribution of effluents. We used metagenomic

SUBMITTER: Rowe WPM 

PROVIDER: S-EPMC5437528 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature