The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol.

ABSTRACT:

Background

Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resonance imaging (MRI) studies have demonstrated sub-acute ischemic lesions in ICH patients. The primary aim of this study is to assess ischemic lesion development in patients randomized to two different BP treatment strategies. We hypothesize aggressive BP reduction is not associated with ischemic injury after ICH.

Methods

The Intracerebral Hemorrhage Acutely Decreasing Blood Pressure Trial II (ICH ADAPT II) is a phase II multi-centre randomized open-label, blinded-endpoint trial. Acute ICH patients (N = 270) are randomized to a systolic blood pressure (SBP) targ

SUBMITTER: Gioia L 

PROVIDER: S-EPMC5437568 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature