Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients - a prospective study.

ABSTRACT:

Background

Circulating pro-inflammatory cytokines were associated with increased relative mortality risk, while immune parameters reflecting improved T-cell function were predictors of survival in hemodialysis (HD) patients. We evaluated in the prospective study whether variants in T helper cell cytokine-associated genes are determinants of mortality in HD patients.

Methods

The study was carried out in 532 prevalent HD subjects who were followed-up for 7 years. HRM analysis was used for IFNL3, IL12A, IL13, and IL4R genotyping. CCL2, IL12B, and IL18 were genotyped using PCR-RFLP analysis. Survival analyses were conducted using the Kaplan-Meier method and the Cox proportional hazard model.

Results

In univariate analyses, IFNL3 rs8099917 was associated with all-cause mor

SUBMITTER: Grzegorzewska AE 

PROVIDER: S-EPMC5437603 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature