Ontology highlight
ABSTRACT:
SUBMITTER: Botella H
PROVIDER: S-EPMC5437814 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20170105 4
<i>Mycobacterium tuberculosis</i> (Mtb) can persist in the human host in a latent state for decades, in part because it has the ability to withstand numerous stresses imposed by host immunity. Prior studies have established the essentiality of the periplasmic protease MarP for Mtb to survive in acidified phagosomes and establish and maintain infection in mice. However, the proteolytic substrates of MarP that mediate these phenotypes were unknown. Here, we used biochemical methods coupled with su ...[more]