Ontology highlight
ABSTRACT:
SUBMITTER: Mohammad H
PROVIDER: S-EPMC5437844 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Mohammad Haroon H Younis Waleed W Chen Lu L Peters Christine E CE Pogliano Joe J Pogliano Kit K Cooper Bruce B Zhang Jianan J Mayhoub Abdelrahman A Oldfield Eric E Cushman Mark M Seleem Mohamed N MN
Journal of medicinal chemistry 20170315 6
The emergence of antibiotic-resistant bacterial species, such as vancomycin-resistant enterococci (VRE), necessitates the development of new antimicrobials. Here, we investigate the spectrum of antibacterial activity of three phenylthiazole-substituted aminoguanidines. These compounds possess potent activity against VRE, inhibiting growth of clinical isolates at concentrations as low as 0.5 μg/mL. The compounds exerted a rapid bactericidal effect, targeting cell wall synthesis. Transposon mutage ...[more]