Unknown

Dataset Information

0

MiR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling.


ABSTRACT: Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated prohypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3'-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway. [BMB Reports 2017; 50(4): 208-213].

SUBMITTER: Lee JS 

PROVIDER: S-EPMC5437965 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2762522 | biostudies-literature
| S-EPMC5856750 | biostudies-literature
| S-EPMC5133975 | biostudies-literature
| S-EPMC8651675 | biostudies-literature
| S-EPMC5424117 | biostudies-literature
| S-EPMC5785447 | biostudies-literature
| S-EPMC8441964 | biostudies-literature
| S-EPMC2970665 | biostudies-literature
| S-EPMC145430 | biostudies-literature
| S-EPMC7640367 | biostudies-literature