Ontology highlight
ABSTRACT:
SUBMITTER: Cho S
PROVIDER: S-EPMC5437976 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20170412 10
miR-23∼27∼24 was recently implicated in restricting Th2 immunity, as well as the differentiation and function of other effector T cell lineages. Interestingly, miR-24, unlike other family members, actually promotes Th1 and Th17 responses. In this article, we show that miR-24 drives the production of IFN-γ and IL-17 in T cells at least in part through targeting TCF1, a transcription factor known for its role in limiting Th1 and Th17 immunity. Surprisingly, whereas TCF1 was previously shown to pro ...[more]