Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
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ABSTRACT:
SUBMITTER: Joshi PK
PROVIDER: S-EPMC5438072 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
Joshi Peter K PK Fischer Krista K Schraut Katharina E KE Campbell Harry H Esko Tõnu T Wilson James F JF
Nature communications 20160331
Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that common variants near the apolipoprotein E and nicotinic acetylcholine receptor subunit alpha 5 genes are associated with lifespan. The effects are strongly sex and age dependent, wi ...[more]
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