Bone and cartilage differentiation of a single stem cell population driven by material interface.
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ABSTRACT:
SUBMITTER: Donnelly H
PROVIDER: S-EPMC5438107 | biostudies-literature | 2017 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Bone and cartilage differentiation of a single stem cell population driven by material interface.
Donnelly Hannah H Smith Carol-Anne CA Sweeten Paula E PE Gadegaard Nikolaj N Meek Rm Dominic RD D'Este Matteo M Mata Alvaro A Eglin David D Dalby Matthew J MJ
Journal of tissue engineering 20170101
Adult stem cells, such as mesenchymal stem cells, are a multipotent cell source able to differentiate towards multiple cell types. While used widely in tissue engineering and biomaterials research, they present inherent donor variability and functionalities. In addition, their potential to form multiple tissues is rarely exploited. Here, we combine an osteogenic nanotopography and a chondrogenic hyaluronan hydrogel with the hypothesis that we can make a complex tissue from a single multipotent c ...[more]
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