Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC5438354 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Wu Zhiyong Z Hu Zhipeng Z Cai Xin X Ren Wei W Dai Feifeng F Liu Huagang H Chang Jinxing J Li Bowen B
Scientific reports 20170519 1
Apoptosis of pulmonary microvascular endothelial cells (PMVECs) was considered to be closely related to the pathogenesis of acute lung injury (ALI). We aim to investigate whether IL-22 plays protective roles in lung injury through inhibiting the apoptosis of PMVECs. ALI model was induced through subcutaneous infusion of angiotensin II (Ang II). Lung injury and infiltration of inflammatory cells were evaluated by determining the PaO<sub>2</sub>/FiO<sub>2</sub>, calculation of dry to weight ratio ...[more]