Ontology highlight
ABSTRACT:
SUBMITTER: Sacchet MD
PROVIDER: S-EPMC5438403 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sacchet Matthew D MD Gotlib Ian H IH
Scientific reports 20170519 1
Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and medial prefrontal cortex (mPFC). We examined whether MDD is characterized by reduced myelin at the whole-brain level ...[more]