Unknown

Dataset Information

0

BCL2 genotypes and prostate cancer survival.


ABSTRACT: The antiapoptotic B?cell lymphoma 2 (BCL2) gene is a key player in cancer development and progression. A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. Aim of the present study was to analyze the role of BCL2-938C>A genotypes in prostate cancer mortality.The association between BCL2-938C>A (rs2279115) genotypes and prostate cancer outcome was studied within the prospective PROCAGENE study comprising 702 prostate cancer patients.During a median follow-up time of 92 months, 120 (17.1%) patients died. A univariate Cox regression model showed a significant association of the CC genotype with reduced cancer-specific survival (CSS; hazard ratio, HR, 2.13, 95% confidence interval, CI, 1.10-4.12; p = 0.024) and overall survival (OS; HR 2.34, 95% CI 1.58-3.47; p < 0.001). In a multivariate Cox regression model including age at diagnosis, risk group, and androgen deprivation therapy, the CC genotype remained a significant predictor of poor CSS (HR 2.05, 95% CI 1.05-3.99; p = 0.034) and OS (HR 2.25, 95% CI 1.51-3.36; p < 0.001).This study provides evidence that the homozygous BCL2-938 CC genotype is associated with OS and C in prostate cancer patients.

SUBMITTER: Renner W 

PROVIDER: S-EPMC5438415 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

BCL2 genotypes and prostate cancer survival.

Renner Wilfried W   Langsenlehner Uwe U   Krenn-Pilko Sabine S   Eder Petra P   Langsenlehner Tanja T  

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20170410 6


<h4>Purpose</h4>The antiapoptotic B‑cell lymphoma 2 (BCL2) gene is a key player in cancer development and progression. A functional single-nucleotide polymorphism (c.-938C>A, rs2279115) in the inhibitory P2 BCL2 gene promoter has been associated with clinical outcomes in various types of cancer. Aim of the present study was to analyze the role of BCL2-938C>A genotypes in prostate cancer mortality.<h4>Methods</h4>The association between BCL2-938C>A (rs2279115) genotypes and prostate cancer outcom  ...[more]

Similar Datasets

| S-EPMC3852642 | biostudies-literature
| S-EPMC3725909 | biostudies-literature
| S-EPMC1287872 | biostudies-literature
| S-EPMC2967822 | biostudies-literature
| S-EPMC9821956 | biostudies-literature
| S-EPMC4872031 | biostudies-literature
| S-EPMC8184896 | biostudies-literature
| S-EPMC6617752 | biostudies-literature
| S-EPMC3622563 | biostudies-literature
| S-EPMC5503531 | biostudies-literature