Ontology highlight
ABSTRACT:
SUBMITTER: Rigolin GM
PROVIDER: S-EPMC5438626 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Rigolin Gian Matteo GM Formigaro Luca L Cavallari Maurizio M Quaglia Francesca Maria FM Lista Enrico E Urso Antonio A Guardalben Emanuele E Martinelli Sara S Saccenti Elena E Bassi Cristian C Lupini Laura L Bardi Maria Antonella MA Volta Eleonora E Tammiso Elisa E Melandri Aurora A Negrini Massimo M Cavazzini Francesco F Cuneo Antonio A
Oncotarget 20170401 17
We investigated whether karyotype analysis and mutational screening by next generation sequencing could predict outcome in 101 newly diagnosed chronic lymphocytic leukemia patients with high-risk features, as defined by the presence of unmutated IGHV gene and/or 11q22/17p13 deletion by FISH and/or TP53 mutations. Cytogenetic analysis showed favorable findings (normal karyotype and isolated 13q14 deletion) in 30 patients, unfavorable (complex karyotype and/or 17p13/11q22 deletion) in 34 cases and ...[more]