Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC5438649 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Li Lei L Shi Baolan B Zheng Wenkai W Xing Wenhua W Zhao Yan Y Li Feng F Xin Daqi D Jin Tianbo T Zhu Yong Y Yang Xuejun X
Oncotarget 20170401 17
Ankylosing spondylitis (AS) is a complex and chronic inflammatory disease with a high heritage. Previous study has shown that IL-1A and IL-1B involved in inflammatory reaction. But little is known about single nucleotide polymorphisms (SNPs) of IL-1A and IL-1B associated with AS. We conducted a case-control study among 267 AS cases and 297 healthy controls from China. In the genetic model analysis, we found the "T" genotype of rs3783550 was associated with decreased AS risk in the dominant model ...[more]