Ontology highlight
ABSTRACT:
SUBMITTER: Shao Q
PROVIDER: S-EPMC5438712 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Shao Qing Q Luo Xinrong X Yang Dejuan D Wang Can C Cheng Qiao Q Xiang Tingxiu T Ren Guosheng G
Oncotarget 20170401 17
Phospholipase C δ1 (PLCD1) encodes an enzyme involved in energy metabolism, calcium homeostasis and intracellular movement. It is located at 3p22 in a region that is frequently deleted in multiple cancers, and the PLCD1 enzyme is a potential tumour suppressor in breast cancer that inhibits matrix metalloprotease (MMP) 7, but the detailed mechanism remains elusive. In this study, we found that PLCD1 was downregulated in breast cancers, and the gain-or-loss functional assay revealed that PLCD1 inh ...[more]