Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC5438714 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Song Hao H Wang Lizhen L Lyu Jiong J Wu Yunteng Y Guo Wei W Ren Guoxin G
Oncotarget 20170401 17
Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, l ...[more]