Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC5438718 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells.
Zhang Jingyang J Li Shuo S Shang Zhaoyang Z Lin Shan S Gao Peng P Zhang Yi Y Hou Shuaiheng S Mo Saijun S Cao Wenbo W Dong Ziming Z Hu Tao T Chen Ping P
Oncotarget 20170401 17
Recent reports showed that regulator of Cullins-1 (ROC1) play an important role in tumor progression in a tumor-specific manner. However, the role and mechanism of ROC1 in esophageal cancer remains elusive. Here we demonstrated that ROC1 was overexpressed in esophageal squamous cell carcinomas, which was positive associated with poor prognosis of esophageal cancer patients. ROC1 knockdown significantly inhibited the growth of esophageal cancer cells in vitro and in vivo. Mechanistically, ROC1 si ...[more]
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