OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling.
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ABSTRACT:
SUBMITTER: Tsai WC
PROVIDER: S-EPMC5438726 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling.
Tsai Wan-Chi WC Bai Li-Yuan LY Chen Yi-Jin YJ Chu Po-Chen PC Hsu Ya-Wen YW Sargeant Aaron M AM Weng Jing-Ru JR
Oncotarget 20170401 17
Pancreatic cancer is an aggressive malignancy that is the fourth leading cause of death worldwide. Since there is a dire need for novel and effective therapies to improve the poor survival rates of advanced pancreatic cancer patients, we analyzed the antitumor effects of OSU-A9, an indole-3-carbinol derivative, on pancreatic cancer cell lines in vitro and in vivo. OSU-A9 exhibited a stronger antitumor effect than gemcitabine on two pancreatic cancer cell lines, including gemcitabine-resistant PA ...[more]
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