Urinary biomarkers and obstructive sleep apnea in patients with Down syndrome.

ABSTRACT:

Study objectives

The study aimed to compare urinary biomarkers in patients with Down syndrome (DS) with and without obstructive sleep apnea (OSA) to those of age- and sex-matched neurotypically developing healthy controls (HC). We further investigated whether we could predict OSA in patients with DS using these biomarkers.

Methods

Urine samples were collected from 58 patients with DS the night before or the morning after their scheduled overnight polysomnogram or both, of whom 47 could be age- and sex-matched to a sample of 43 HC. Concentrations of 12 neurotransmitters were determined by enzyme-linked immunosorbent assay. Log-transformed creatinine-corrected assay levels were normalized. Normalized z-scores were compared between patients with DS vs. HC, between patients with

SUBMITTER: Elsharkawi I 

PROVIDER: S-EPMC5439300 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature