Ontology highlight
ABSTRACT:
SUBMITTER: Yan N
PROVIDER: S-EPMC5439420 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20170501 5
The innate immune system is the first line of defense against invading pathogens. One important feature of innate immune recognition is self versus nonself discrimination. The selectivity for microbial ligands is achieved through substrate motif specificity, spatial compartmentalization, and functions of negative regulators. Loss-of-function mutations in negative regulators or gain-of-function mutations in drivers of innate immune signaling have been associated with autoimmune diseases such as l ...[more]