Ontology highlight
ABSTRACT:
SUBMITTER: Song YH
PROVIDER: S-EPMC544037 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Song Yao-Hua YH Li Yangxin Y Du Jie J Mitch William E WE Rosenthal Nadia N Delafontaine Patrick P
The Journal of clinical investigation 20050201 2
Advanced congestive heart failure is associated with activation of the renin-angiotensin system and skeletal muscle wasting. We previously showed that angiotensin II infusion in rats produces cachexia secondarily to increased muscle proteolysis and also decreases levels of circulating and skeletal muscle IGF-1. Here we show that angiotensin II markedly downregulates phospho-Akt and activates caspase-3 in skeletal muscle, leading to actin cleavage, an important component of muscle proteolysis, an ...[more]