Lack of inflammatory gene expression in bats: a unique role for a transcription repressor.

ABSTRACT: In recent years viruses similar to those that appear to cause no overt disease in bats have spilled-over to humans and other species causing serious disease. Since pathology in such diseases is often attributed to an over-active inflammatory response, we tested the hypothesis that bat cells respond to stimulation of their receptors for viral ligands with a strong antiviral response, but unlike in human cells, the inflammatory response is not overtly activated. We compared the response of human and bat cells to poly(I:C), a viral double-stranded RNA surrogate. We measured transcripts for several inflammatory, interferon and interferon stimulated genes using quantitative real-time PCR and observed that human and bat cells both, when stimulated with poly(I:C), contained higher levels of trans

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC5440382 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature