Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC5440603 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Yang Zuozhang Z Su Zhenyi Z DeWitt Judy Park JP Xie Lin L Chen Yongbin Y Li Xiaojuan X Han Lei L Li Dongqi D Xia Junfeng J Zhang Ya Y Yang Yihao Y Jin Congguo C Zhang Jing J Li Su S Li Kun K Zhang Zhiping Z Qu Xin X He Zewei Z Chen Yanjin Y Shen Yan Y Ren Mingyan M Yuan Zhongqin Z
EBioMedicine 20170411
Bone is one of the most preferred sites of metastasis in lung cancer. Currently, bisphosphonates and denosumab are major agents for controlling tumor-associated skeletal-related events (SREs). However, both bisphosphonates and denosumab significantly increase the risk for jaw osteonecrosis. Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and the most frequently prescribed cholesterol-lowering agents, have been reported to inhibit tumor progression and induce autopha ...[more]