Ontology highlight
ABSTRACT:
SUBMITTER: Soyer N
PROVIDER: S-EPMC5440870 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Soyer Nur N Tezcanlı Kaymaz Burçin B Cömert Özkan Melda M Aktan Çağdaş Ç Küçükaslan Ali Şahin AŞ Şahin Fahri F Kosova Buket B Saydam Güray G
Turkish journal of haematology : official journal of Turkish Society of Haematology 20170220 2
We aimed to determine the genotype distribution, allele frequency, and prognostic impact of IDH1/2, TET2, and ASXL1 single nucleotide polymorphisms (SNPs) in myeloproliferative neoplasms (MPNs). TET2 (rs763480), ASXL1 (rs2208131), and IDH1 (rs11554137) variant homozygous genotype frequencies were found at rates of 1.5%, 9.2%, and 2.3%, respectively. No IDH2 SNP was identified. IDH1 and TET2 frequencies were 5% in essential thrombocythemia (ET) and 1.7% in ET and 5% in primary myelofibrosis (PMF) ...[more]