Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial.
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ABSTRACT:
SUBMITTER: Pauls MMH
PROVIDER: S-EPMC5440904 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Perfusion by Arterial Spin labelling following Single dose Tadalafil In Small vessel disease (PASTIS): study protocol for a randomised controlled trial.
Pauls Mathilde M H MMH Clarke Natasha N Trippier Sarah S Betteridge Shai S Howe Franklyn A FA Khan Usman U Kruuse Christina C Madigan Jeremy B JB Moynihan Barry B Pereira Anthony C AC Rolfe Debbie D Rostrup Egill E Haig Caroline E CE Barrick Thomas R TR Isaacs Jeremy D JD Hainsworth Atticus H AH
Trials 20170522 1
<h4>Background</h4>Cerebral small vessel disease is a common cause of vascular cognitive impairment in older people, with no licensed treatment. Cerebral blood flow is reduced in small vessel disease. Tadalafil is a widely prescribed phosphodiesterase-5 inhibitor that increases blood flow in other vascular territories. The aim of this trial is to test the hypothesis that tadalafil increases cerebral blood flow in older people with small vessel disease.<h4>Methods/design</h4>Perfusion by Arterial ...[more]
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