Associations of MTHFR C677T polymorphism with insulin resistance, results of NURSE Study (Nursing Unacquainted Related Stress Etiologies).

ABSTRACT: BACKGROUND:The insulin resistance syndrome is one of the major contributors of metabolic syndrome, diabetes Type 2 and atherosclerotic cardiovascular disease. A common mutation (677C to T; Ala to Val) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased specific MTHFR activity and elevation of the homocysteine. The aim of this study is investigation of association between MTHFR 677C > T polymorphism with insulin resistance by using HOMA (Homeostasis Model Assessment) index in nurses who are potentially prone to develop insulin resistance because of unfavorable effects of shift work. METHOD:Nursing Unacquainted Related Stress Etiologies Study (Nurse Study) was conducted in five different educational hospitals of Tehran University of Medical Science (TUMS). Th

SUBMITTER: Kheradmand M 

PROVIDER: S-EPMC5441014 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature