Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5441181 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wang Yanxiao Y Hou Ning N Cheng Xuan X Zhang Jishuai J Tan Xiaohong X Zhang Chong C Tang Yuling Y Teng Yan Y Yang Xiao X
International journal of biological sciences 20170516 5
Previous studies have suggested that enhancer zeste homolog 2 (Ezh2), a histone methyltransferase subunit of polycomb repressive complex 2 (PRC2), acts as an oncogene in lung adenocarcinoma (ADC) development. However, we found that in human lung ADC samples, deletion and mutations of <i>EZH2</i> were also frequently present, with 14% of patients harboring loss-of-function <i>EZH2</i> alterations. To explore the effect of <i>Ezh2</i> loss on lung tumor formation, lung epithelial <i>Ezh2</i> gene ...[more]