Ontology highlight
ABSTRACT:
SUBMITTER: Beach RR
PROVIDER: S-EPMC5441241 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Beach Rebecca R RR Ricci-Tam Chiara C Brennan Christopher M CM Moomau Christine A CA Hsu Pei-Hsin PH Hua Bo B Silberman Rebecca E RE Springer Michael M Amon Angelika A
Cell 20170401 2
Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromosomes to show that the aneuploid state causes non-genetic phenotypic variability. Yeast cell populations harboring the same defined aneuploidy exhibit heterogeneity in cell-cycle progression and respons ...[more]