Ontology highlight
ABSTRACT:
SUBMITTER: Scholz I
PROVIDER: S-EPMC544128 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Scholz Isabel I Arvidson Brian B Huseby Doug D Barklis Eric E
Journal of virology 20050201 3
The N-terminal domains (NTDs) of the human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein have been modeled to form hexamer rings in the mature cores of virions. In vitro, hexamer ring units organize into either tubes or spheres, in a pH-dependent fashion. To probe factors which might govern hexamer assembly preferences in vivo, we examined the effects of mutations at CA histidine residue 84 (H84), modeled at the outer edges of NTD hexamers, as well as a nearby histidine (H87) in the ...[more]