Dataset Information

Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Dental caries (DC) are more prevalent in individuals with diabetes than in healthy individuals. However, the association between glycaemic control and DC has not been well characterized in patients with type 2 diabetes mellitus (T2DM). We therefore assessed the association between glycated haemoglobin (HbA1c) serum concentrations and the prevalence of DC in patients with T2DM.

Methods

Retrospective analyses of data pertaining to 108 Japanese patients with T2DM hospitalized because of poor or worsened glycaemic control were included. We divided the patients based on HbA1c into two groups: HbA1c level ?75?mmol/mol (9.0%) as poorly controlled T2DM, and HbA1c level <75?mmol/mol (9.0%) as a control group. We compared the association of lifestyle factors, dental caries, and periodontal health between patients with poorly controlled T2DM and controls. Stepwise multiple regression analyses were performed to evaluate the association between HbA1c, the absolute number of decayed teeth (DT), the sum of decayed, missing, and filled teeth, and the Met Need Index (MNI).

Results

DT was higher and MNI was lower in patients with poorly controlled T2DM as compared to that in controls (P?=?0.006 and P?=?0.004, respectively). Multiple regression analyses revealed a significant association between HbA1c levels and DT (adjusted ??=?0.039, 95% confidence interval [CI], 0.005 to 0.072, P?=?0.025) and the MNI (adjusted ??=?-0.216, 95% CI -0.374 to -0.058, P?=?0.008).

Conclusions

DT and MNI were associated with HbA1c in T2DM patients.

SUBMITTER: Yonekura S

PROVIDER: S-EPMC5441370 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus.

Yonekura Satoru S Usui Masato M Murano Shunichi S

Upsala journal of medical sciences 20170303 2

<h4>Background</h4>Dental caries (DC) are more prevalent in individuals with diabetes than in healthy individuals. However, the association between glycaemic control and DC has not been well characterized in patients with type 2 diabetes mellitus (T2DM). We therefore assessed the association between glycated haemoglobin (HbA1c) serum concentrations and the prevalence of DC in patients with T2DM.<h4>Methods</h4>Retrospective analyses of data pertaining to 108 Japanese patients with T2DM hospitali ...[more]

PMID: 28276781

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Project description:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes in the micro- and macrovasculature. These substrates, including methylglyoxal and 4-hydroxynonenal formed from glucose and lipids, cause protein carbonylation and mitochondrial dysfunction, forming advanced glycation end products (AGEs). The present study aimed to confirm the association between the inactive ALDH2*2 allele and diabetic retinopathy (DR).A retrospective longitudinal analysis was conducted, among 234 Japanese patients with type 2 diabetes mellitus (DM) (156 males and 78 females) who had no DR signs at baseline and were treated for more than half a year. The ALDH2*1/*2 alleles were determined using a real-time TaqMan allelic discrimination assay. Multivariate-adjusted hazard ratios (HRs) and 95% confidential intervals (CIs) for the cumulative incidence of the development of DR were examined using a Cox proportional hazard model, taking drinking habits and the serum ?-glutamyltransferase (GGT) level into consideration.The frequency of the ALDH2*2 allele was 22.3%. Fifty-two subjects cumulatively developed DR during the follow-up period of 5.5 ± 2.5 years. The ALDH2*2 allele carriers had a significantly higher incidence of DR than the non-carriers (HR: 1.92; P = 0.02). The incidence of DR was significantly higher in the drinkers with the ALDH2*2 allele than in those with the ALDH2*1/*1 genotype (HR: 2.61; P = 0.03), while the incidence of DR in the non-drinkers did not differ significantly between the ALDH2 genotype groups (P > 0.05). The incidence of DR was significantly higher in the ALDH2*2 allele carriers with a high GGT level than in the non-carriers with a high or low GGT level (HR: 2.45; P = 0.03; and HR: 2.63; P = 0.03, respectively).To the best of our knowledge, this is the first report of a significant association between the ALDH2*2 allele and the incidence of DR. These findings provide additional evidence that ALDH2 protects both microvasculature and macrovasculature against reactive aldehydes generated under conditions of sustained oxidative stress, although further investigations in larger cohorts are needed to verify the results.

Dataset Information

Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus.

Background

Methods

Results

Conclusions

Publications

Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus.

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