Ontology highlight
ABSTRACT:
SUBMITTER: Rezaeian AH
PROVIDER: S-EPMC5441459 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Rezaeian Abdol-Hossein AH Li Chien-Feng CF Wu Ching-Yuan CY Zhang Xian X Delacerda Jorge J You M James MJ Han Fei F Cai Zhen Z Jeong Yun Seong YS Jin Guoxiang G Phan Liem L Chou Ping-Chieh PC Lee Mong-Hong MH Hung Mien-Chie MC Sarbassov Dos D Lin Hui-Kuan HK
Nature cell biology 20161205 1
The understanding of how hypoxia stabilizes and activates HIF1α in the nucleus with related oncogenic signals could revolutionize targeted therapy for cancers. Here, we find that histone H2AX displays oncogenic activity by serving as a crucial regulator of HIF1α signalling. H2AX interacts with HIF1α to prevent its degradation and nuclear export in order to allow successful VHL-independent HIF1α transcriptional activation. We show that mono-ubiquitylation and phosphorylation of H2AX, which are st ...[more]