NY-ESO-1 expression in DCIS: A new predictor of good prognosis.
Ontology highlight
ABSTRACT: Background
At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). A recent survey by our group has shown that NY-ESO-1 and MAGEA are both expressed in DCIS. This study was aimed at determining whether expression of these antigens was related to the later development of IDC.Results
14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. Only one of those DCIS cases that relapsed was positive for NYESO-1 at diagnosis. In contrast, DCIS samples of 15 of the 28 (54%) of those patients who remained disease-free expressed NY-ESO-1. (Permutation chi square p=0.0033).Methods
We identified 42 patients with DCIS, and followed them up for more than 10 years. NY-ESO-1 and MAGEA were demonstrated by immunostaining as were CD8+ infiltrates on all sections together with the conventional markers, ER, PR, and HER2.Conclusions
Expression of NY-ESO-1 may predict those patients who will not subsequently develop invasive breast cancer and could therefore potentially be helpful in defining prognosis in patients with DCIS.
SUBMITTER: Coombes RC
PROVIDER: S-EPMC5441475 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
NY-ESO-1 expression in DCIS: A new predictor of good prognosis.
Coombes R Charles RC Caballero Otavia L OL Shousha Sami S Ghaem-Maghami Sadaf S Woodley-Barker Laura L Wilhelm-Benartzi Charlotte S CS Neville A Munro AM
Oncoscience 20170301 3-4
<h4>Background</h4>At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). A recent survey by our group has shown that NY-ESO-1 and MAGEA are both expressed in DCIS. This study was aimed at determining whether expression of these antigens was related to the later development of IDC.<h4>Results</h4>14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. Only one of tho ...[more]
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