Ontology highlight
ABSTRACT:
SUBMITTER: Vitale AM
PROVIDER: S-EPMC5441549 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Vitale Alejandra M AM Matigian Nicholas A NA Cristino Alexandre S AS Nones Katia K Ravishankar Sugandha S Bellette Bernadette B Fan Yongjun Y Wood Stephen A SA Wolvetang Ernst E Mackay-Sim Alan A
NPJ schizophrenia 20170123
DNA methylation of gene promoter regions represses transcription and is a mechanism via which environmental risk factors could affect cells during development in individuals at risk for schizophrenia. We investigated DNA methylation in patient-derived cells that might shed light on early development in schizophrenia. Induced pluripotent stem cells may reflect a "ground state" upon which developmental and environmental influences would be minimal. Olfactory neurosphere-derived cells are an adult- ...[more]