Structural basis of the day-night transition in a bacterial circadian clock.
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ABSTRACT:
SUBMITTER: Tseng R
PROVIDER: S-EPMC5441561 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Structural basis of the day-night transition in a bacterial circadian clock.
Tseng Roger R Goularte Nicolette F NF Chavan Archana A Luu Jansen J Cohen Susan E SE Chang Yong-Gang YG Heisler Joel J Li Sheng S Michael Alicia K AK Tripathi Sarvind S Golden Susan S SS LiWang Andy A Partch Carrie L CL
Science (New York, N.Y.) 20170316 6330
Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a set of output signaling proteins, SasA and CikA, which transduce this rhythm to control gene expression. Here, we describe crystal and nuclear magnetic resonance structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how the metamorphic ...[more]
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