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Using relative handgrip strength to identify children at risk of sarcopenic obesity.

ABSTRACT: Identifying children at risk of developing childhood sarcopenic obesity often requires specialized equipment and costly testing procedures, so cheaper and quicker methods would be advantageous, especially in field-based settings. The purpose of this study was to determine the relationships between the muscle-to-fat ratio (MFR) and relative handgrip strength, and to determine the ability of handgrip strength relative to body mass index (grip-to-BMI) to identify children who are at risk of developing sarcopenic obesity. Grip-to-BMI was measured in 730 Czech children (4 to 14 yrs). Bioelectrical impedance was used to estimate body fat mass and skeletal muscle mass, from which the MFR was calculated. The area under the curve (AUC) was 0.791 (95% CI 0.692-0.890, p ? 0.001) in girls 4-9; 0.789 (95% CI 0.688-0.890, p ? 0.001) in girls 10-14 years old; 0.719 (95% CI 0.607-0.831, p = 0.001) in boys 4-9; and 0.896 (95% CI 0.823-0.969, p ? 0.001) in boys 10-14 years old. Calculated using the grip-to-BMI ratio, the OR (95% CI) for girls to be at risk of sarcopenic obesity identified by MFR was 9.918 (4.243-23.186, p ? 0.001) and was 11.515 (4.280-30.982, p ? 0.001) for boys. The grip-to-BMI ratio can be used to predict the presence of sarcopenic obesity in children, which can play a role in pediatric health interventions.

SUBMITTER: Steffl M

PROVIDER: S-EPMC5441624 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Using relative handgrip strength to identify children at risk of sarcopenic obesity.

Steffl Michal M Chrudimsky Jan J Tufano James J JJ

PloS one 20170523 5

Identifying children at risk of developing childhood sarcopenic obesity often requires specialized equipment and costly testing procedures, so cheaper and quicker methods would be advantageous, especially in field-based settings. The purpose of this study was to determine the relationships between the muscle-to-fat ratio (MFR) and relative handgrip strength, and to determine the ability of handgrip strength relative to body mass index (grip-to-BMI) to identify children who are at risk of develop ...[more]

PMID: 28542196

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Project description:Excess central adiposity accelerates the decline of muscle strength in older people. Additionally, hyperglycemia, independent of associated comorbidities, is related to the loss of muscle mass and strength, and contributes to functional impairment in older adults. We studied the mediation effect of glucose levels, in the relationship between abdominal obesity and relative handgrip strength (HGS). A total of 1571 participants (60.0% women, mean age 69.1 ± 7.0 years) from 86 municipalities were selected following a multistage area probability sampling design. Measurements included demographic and anthropometric/adiposity markers (weight, height, body mass index, and waist circumference). HGS was measured using a digital dynamometer for three sets and the mean value was recorded. The values were normalized to body weight (relative HGS). Fasting glucose was analyzed by enzymatic colorimetric methods. Mediation analyses were performed to identify associations between the independent variable (abdominal obesity) and outcomes (relative HGS), as well as to determine whether fasting glucose levels mediated the relationship between excess adiposity and relative HGS. A total of 1239 (78.8%) had abdominal obesity. Abdominal obesity had a negative effect on fasting glucose (? = 9.04, 95%CI = 5.87 to 12.21); while fasting glucose to relative HGS was inversely related (? = -0.003, 95%CI = -0.005 to -0.001), p < 0.001. The direct effect of abdominal obesity on relative HGS was statistically significant (? = -0.069, 95%CI = -0.082 to -0.057), p < 0.001. Lastly, fasting glucose levels mediates the detrimental effect of abdominal obesity on relative HGS (indirect effect ? = -0.002, 95%CI = -0.004 to -0.001), p < 0.001. Our results suggest that the glucose level could worsen the association between abdominal obesity status and lower HGS. Thus, it is plausible to consider fasting glucose levels when assessing older adults with excess adiposity and/or suspected loss of muscle mass.

Dataset Information

Using relative handgrip strength to identify children at risk of sarcopenic obesity.

Publications

Using relative handgrip strength to identify children at risk of sarcopenic obesity.

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