Unknown

Dataset Information

0

Design and rationale of the high-sensitivity Troponin T Rules Out Acute Cardiac Insufficiency Trial.


ABSTRACT: BACKGROUND:Acute heart failure (AHF) is a common presentation in the Emergency Department (ED), and most patients are admitted to the hospital. Identification of patients with AHF who have a low risk of adverse events and are suitable for discharge from the ED is difficult, and an objective tool would be useful. METHODS:The highly sensitive Troponin T Rules Out Acute Cardiac Insufficiency Trial (TACIT) will enroll ED patients being treated for AHF. Patients will undergo standard ED evaluation and treatment. High-sensitivity troponin T (hsTnT) will be drawn at the time of enrollment and 3 hours after the initial draw. The initial hsTnT draw will be no more than 3 hours after initiation of therapy for AHF (vasodilator, loop diuretic, noninvasive ventilation). Treating clinicians will be blinded to hsTnT results. We will assess whether hsTnT, as a single measurement or in series, can accurately predict patients at low risk of short-term adverse events. CONCLUSION:TACIT will explore the value of hsTnT measurements in isolation, or in combination with other markers of disease severity, for the identification of ED patients with AHF who are at low risk of short-term adverse events.

SUBMITTER: Hunter BR 

PROVIDER: S-EPMC5441668 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Design and rationale of the high-sensitivity Troponin T Rules Out Acute Cardiac Insufficiency Trial.

Hunter Benton R BR   Collins Sean P SP   Fermann Gregory J GJ   Levy Phillip D PD   Shen Changyu C   Ayaz Syed Imran SI   Cole Mette L ML   Miller Karen F KF   Soliman Adam A AA   Pang Peter S PS  

Pragmatic and observational research 20170518


<h4>Background</h4>Acute heart failure (AHF) is a common presentation in the Emergency Department (ED), and most patients are admitted to the hospital. Identification of patients with AHF who have a low risk of adverse events and are suitable for discharge from the ED is difficult, and an objective tool would be useful.<h4>Methods</h4>The highly sensitive Troponin T Rules Out Acute Cardiac Insufficiency Trial (TACIT) will enroll ED patients being treated for AHF. Patients will undergo standard E  ...[more]

Similar Datasets

| S-EPMC6719714 | biostudies-literature
| S-EPMC8177493 | biostudies-literature
| S-EPMC4107722 | biostudies-literature
| S-EPMC7141983 | biostudies-literature
| S-EPMC7449512 | biostudies-literature
| S-EPMC7044902 | biostudies-literature
| S-EPMC4435896 | biostudies-literature
| S-EPMC11365000 | biostudies-literature
| S-EPMC5421194 | biostudies-literature
| S-EPMC5710293 | biostudies-literature